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BM212

Chemical Structure : BM212

CAS No.: 146204-42-4

BM212 (BM-212, BM 212)

Catalog No.: PC-42236Not For Human Use, Lab Use Only.

BM212 is a novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3.

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Biological Activity

BM212 is a novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3.
BM212 also has marked activity against several species of yeasts, including Candida albicans and Cryptococcus neoformans.
BM212 is also highly efficacious against mycobacteria which show resistance to the most common traditional drugs.

Physicochemical Properties

M.Wt 414.3707
Formula C23H25Cl2N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Piperazine, 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-

References

1. La Rosa V, et al. Antimicrob Agents Chemother. 2012 Jan;56(1):324-31.

2. Deidda D, et al. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7.

3. Li W, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6413-23.

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