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Chemical Structure : Q203
CAS No.: 1334719-95-7
Catalog No.: PC-42302Not For Human Use, Lab Use Only.
Telacebec (Q203, IAP6) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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Telacebec (Q203, IAP6) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
Telacebec (Q203) does not inhibit any of thecytochrome P450 (CYP450) isoenzymes.
Telacebec (Q203) targets the respiratory cytochrome bc1 complex and triggers a rapid ATP depletion in M. tuberculosis, also inhibits the growth of MDR and XDR M. tuberculosis.
Telacebec (Q203) deonstrates potency in mouse model of tuberculosis and displays pharmacokinetic and safety profiles.
| M.Wt | 557.0064296 | |
| Formula | C29H28ClF3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
Imidazo[1,2-a]pyridine-3-carboxamide, 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]phenyl]methyl]- |
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1. Pethe K, et al. Nat Med. 2013 Sep;19(9):1157-60.
2. Kang S, et al. J Med Chem. 2014 Jun 26;57(12):5293-305.
3. Jang J, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02637-16.
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