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Chemical Structure : ACHN-975
Catalog No.: PC-38311Not For Human Use, Lab Use Only.
ACHN-975 (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).
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ACHN-975 (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).
ACHN-975 is potent against the P. aeruginosa isolates with MIC50 of 0.06 ug/mL and MIC90 of 0.25 ug/mL.
ACHN-975 demonstrated effectivity in a neutropenic mouse thigh model with P. aeruginosa ATCC 27853.
| M.Wt | 369.421 | |
| Formula | C20H23N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cohen F, et al. ChemMedChem. 2019 Aug 20;14(16):1560-1572.
2. Krause KM, et al. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00977-19.
3. Fan S, et al. Molecules. 2021 Mar 7;26(5):1451.
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