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ANY1

Chemical Structure : ANY1

CAS No.: 482574-02-7

ANY1 (FosA inhibitor ANY1)

Catalog No.: PC-36006Not For Human Use, Lab Use Only.

ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA).

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    Biological Activity

    ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA).
    ANY1 binds to wild-type and mutant FosA3 measured by fluorescence quenching with Kd vales of 440-4880 nM.
    ANY1 potentiates Fosfomycin (FOM) activity in representative Gram-negative pathogens.

    Physicochemical Properties

    M.Wt 537.088
    Formula C15H7Br2N9O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-bromo-6-[3-(3-bromo-2-oxo-1H-pyrazolo[1,5-a]pyrimidin-6-yl)-4-nitro-1H-pyrazol-5-yl]-1H-pyrazolo[1,5-a]pyrimidin-2-one

    References

    1. Tomich AD, et al. Antimicrob Agents Chemother. 2019 Jan 14. pii: AAC.01524-18.

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