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Chemical Structure : Didemethylclomipramine
Catalog No.: PC-36045Not For Human Use, Lab Use Only.
Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine.
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Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine.
Didemethylclomipramine shows growth inhibition of both Mycobacterium smegmatis and M. tuberculosis cells via inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), inhibits DNA relaxation activity of MttopoI.
Didemethylclomipramine shows MIC vales of 30 μM and 60 μM for M. smegmatis and M. tuberculosis, respectively.
| M.Wt | 300.83 | |
| Formula | C18H21ClN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Godbole AA, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1549-57.
2. Ekins S, et al. Tuberculosis (Edinb). 2017 Mar;103:52-60.
3. Johnson-Davis KL, et al. Methods Mol Biol. 2012;902:175-84.
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