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GSK693

Chemical Structure : GSK693

CAS No.: 1372891-37-6

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GSK693 (GSK-693, GSK2505693A)

Catalog No.: PC-36157Not For Human Use, Lab Use Only.

GSK693 (GSK2505693A) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM, shows equally potent activity against M. tuberculosis H37Rv both intra and extracellularly (MIC=0.2 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GSK693 (GSK2505693A) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM, shows equally potent activity against M. tuberculosis H37Rv both intra and extracellularly (MIC=0.2 uM).
    GSK693 exhibits activities against multidrug (MDR) and extensively (XDR) drug-resistant clinical isolates as well as in TB murine models when orally dosed.

    Physicochemical Properties

    M.Wt 419.54
    Formula C16H17N7OS3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-(4-methylthiazol-2-yl)-1-(5-((1-((2-methylthiazol-4-yl)methyl)-1H-pyrazol-3-yl)amino)-1,3,4-thiadiazol-2-yl)ethanol

    References

    1. Martínez-Hoyos M, et al. EBioMedicine. 2016 Jun;8:291-301.

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