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Chemical Structure : MAC-0452936
Catalog No.: PC-23136Not For Human Use, Lab Use Only.
MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).
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MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).
MAC-0452936 inhibits Lgt activity with an IC50 of 0.59 μM and 1.45 μM for Lgt purified using amphipol and DDM lipid matrices, respectively.
MAC-0452936 inhibits the growth of E. coli through inhibition of Lgt.
MAC-0452936 demonstrates potent activity against wild-type isolates of E. coli and S. Tm when combined with the antibiotic adjuvant SPR741, but not Gram-negative pathogens A. baumannii, K. pneumoniae, K. aerogenes, or P. aeruginosa.
| M.Wt | 317.40 | |
| Formula | C17H19NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rachwalski K, et al. iScience. 2024 Sep 5;27(10):110894.
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