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Chemical Structure : Ibezapolstat
CAS No.: 1275582-97-2
Catalog No.: PC-38361Not For Human Use, Lab Use Only.
Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL).
ACX-362E is a potent inhibitor of diverse clinical isolates of C. difficile with MIC50 of 2 ug/ml and MIC90 of 4 ug/ml.
ACX-362E shows preferential activity against C. difficile PolC over those of other organisms in vitro.
ACX-362E demonstrated therapeutic potential for the oral treatment of Clostridioides difficile infection (CDI).
| M.Wt | 423.298 | |
| Formula | C18H20Cl2N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((3,4-dichlorobenzyl)amino)-7-(2-morpholinoethyl)-1,7-dihydro-6H-purin-6-one |
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1. van Eijk E, et al. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01363-18.
2. Xu WC, et al. Bioorg Med Chem. 2019 Aug 1;27(15):3209-3217.
3. Murray B, et al. J Antimicrob Chemother. 2020 Aug 1;75(8):2149-2155.
4. Kullar R, et al. J Exp Pharmacol. 2020 Oct 9;12:371-384.
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