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MGB-BP-3

Chemical Structure : MGB-BP-3

CAS No.: 1000277-08-6

MGB-BP-3

Catalog No.: PC-38362Not For Human Use, Lab Use Only.

MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI).

    Physicochemical Properties

    M.Wt 631.737
    Formula C36H37N7O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-1-methyl-4-(1-methyl-4-(4-(2-(quinolin-3-yl)vinyl)benzamido)-1H-pyrrole-2-carboxamido)-N-(2-morpholinoethyl)-1H-pyrrole-2-carboxamide

    References

    1. Louie T, et al. Phase IIa Dose Escalation Treatment of Clostridioides Difficile-Associated Diarrhea with MGB-BP-3, a Novel First in Class DNA Minor Grove Binding Antibiotic. ECCMID; 2020.

    2. Ravina Kullar, et al. J Exp Pharmacol. 2020 Oct 9;12:371-384.

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