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MGB-BP-3

Chemical Structure : MGB-BP-3

CAS No.: 1000277-08-6

MGB-BP-3

Catalog No.: PC-38362Not For Human Use, Lab Use Only.

MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI).

Physicochemical Properties

M.Wt 631.737
Formula C36H37N7O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-1-methyl-4-(1-methyl-4-(4-(2-(quinolin-3-yl)vinyl)benzamido)-1H-pyrrole-2-carboxamido)-N-(2-morpholinoethyl)-1H-pyrrole-2-carboxamide

References

1. Louie T, et al. Phase IIa Dose Escalation Treatment of Clostridioides Difficile-Associated Diarrhea with MGB-BP-3, a Novel First in Class DNA Minor Grove Binding Antibiotic. ECCMID; 2020.

2. Ravina Kullar, et al. J Exp Pharmacol. 2020 Oct 9;12:371-384.

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