Chemical Structure : CMX410
CAS No.:
3027135-80-1
CMX410
(CMX-410)
Catalog No.: PC-25221Not For Human Use, Lab Use Only.
CMX410 (CMX-410) is a potent, specific, irreversible inhibitor of Mycobacterium tuberculosis (Mtb) Pks13, targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis, inhibits MABA H37Rv strain with MIC90 of 39 nM and MBC of 78 nM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CMX410 (CMX-410) is a potent, specific, irreversible inhibitor of Mycobacterium tuberculosis (Mtb) Pks13, targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis, inhibits MABA H37Rv strain with MIC90 of 39 nM and MBC of 78 nM.
CMX410 shows potent activity against all Mtb strains tested, including XDR clinical isolates, with reduced activity for non-TB mycobacteria and inactivity against a panel of gram-positive and gram-negative bacteria.
CMX410 (25-100 mg/kg QD) is active in acute TB infection in BALB/c mice.
CMX410 represents the most advanced inhibitor developed to target and inhibit Pks13 or any other polyketide synthase.
Physicochemical Properties
|
M.Wt
|
478.42
|
|
Formula
|
C16H13F3N4O6S2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-((2,6-difluoro-4-(3-(methylsulfonamido)-1H-1,2,4-triazol-1-yl)benzyl)oxy)phenyl sulfurofluoridate
|
References
1. Krieger IV, et al. Nature. 2025 Jul 30. doi: 10.1038/s41586-025-09286-3.
Contact Us
sales@probechem.com
