Chemical Structure : TXH9179
CAS No.:
TXH9179
(TXH-9179 )
Catalog No.: PC-25154Not For Human Use, Lab Use Only.
TXH9179 is a next-generation benzamide-based FtsZ inhibitor, exhibits braod antibacterial activity against Clinical Isolates of MSSA, MRSA, VISA, VRSA, and LRSA with MIC of 0.25-0.5 ug/mL.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TXH9179 is a next-generation benzamide-based FtsZ inhibitor, exhibits braod antibacterial activity against Clinical Isolates of MSSA, MRSA, VISA, VRSA, and LRSA with MIC of 0.25-0.5 ug/mL.
TXH9179 treatment caused the mislocalization of FtsZ to one or more large foci at the cell periphery.
TXH9179 is 4-fold more potent than TXA707 against a library of 55 methicillin-sensitive S. aureus (MSSA) and MRSA clinical isolates, including MRSA isolates resistant to vancomycin and linezolid.
TXH9179 induces changes in MRSA cell morphology, cell division, and FtsZ localization.
TXH9179 is not associated with any mammalian cytotoxicity.
Physicochemical Properties
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M.Wt
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345.32
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Formula
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C16H9F2N3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((6-ethynylthiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide
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References
1. Eric Bryan, et al. ACS Chem Biol. 2023 Mar 17;18(3):629-642.
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