Chemical Structure : UCM53
CAS No.:
2468847-23-4
UCM53
Catalog No.: PC-25152Not For Human Use, Lab Use Only.
UCM53 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 1.3 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 13 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UCM53 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 1.3 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 13 uM.
UCM53 induces filamentation of B. subtilis cells, indicating inhibition of cell division.
UCM53 induces FtsZ delocalization with formation of numerous punctuate foci and distorted ring structures.
UCM53 is active on methicillin-resistant Staphylococcus aureus, ampicillin- and levofloxacin-resistant Enterococcus faecium, and levofloxacin-resistant Enterococcus faecalis and weakly active on Streptococcus pneumoniae.
UCM53 competitively inhibits GTP binding to FtsZ, effectively inhibits the growth of Gram-positive pathogens.
Physicochemical Properties
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M.Wt
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469.27
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Formula
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C24H14Cl2O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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naphthalene-1,3-diyl bis(3-chloro-4-hydroxybenzoate)
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References
1. Ruiz-Avila LB, et al. ACS Chem Biol. 2013 Sep 20;8(9):2072-83.
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