Chemical Structure : JNJ-6640
CAS No.:
JNJ-6640
(JNJ6640)
Catalog No.: PC-24906Not For Human Use, Lab Use Only.
JNJ-6640 is a first-in-class potent, selective inhibitor targeting Mycobacterium tuberculosis (Mtb) PurF (IC50=1 nM), exhibits high potency against M.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNJ-6640 is a first-in-class potent, selective inhibitor targeting Mycobacterium tuberculosis (Mtb) PurF (IC50=1 nM), exhibits high potency against M. tuberculosis in vitro with MIC90 of 8.6 nM and MBC99.9 of 140 nM.
JNJ-6640 inhibits purine biosynthesis and affects DNA replication.
JNJ-6640 binds near the phosphoribosyl transferase (PRTase) active site in an AlphaFold model of M. tuberculosis PurF (MtPurF).
JNJ-6640 is more than 10,000-fold less active against human homologue PPAT (IC50=14 uM).
JNJ-6640 demonstrated ex vivo and in vivo efficacy.
Physicochemical Properties
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M.Wt
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340.36
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Formula
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C17H17FN6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-5-fluoro-4-(3-methyl-1H pyrazol-5-yloxy)-2-(3-(pyridin-4-yl)pyrrolidin-1-yl)pyrimidine
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References
1. Lamprecht DA, et al. Nature. 2025 Jun 18. doi: 10.1038/s41586-025-09177-7.
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