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Chemical Structure : Brilacidin tetrahydrochloride
CAS No.: 1224095-99-1
Catalog No.: PC-47040Not For Human Use, Lab Use Only.
Brilacidin (PMX-30063) is a synthetic, non-peptide, defensin-mimetic compound, exhibits broad-spectrum anti-microbial and anti-SARS-CoV-2 activities.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Brilacidin (PMX-30063) is a synthetic, non-peptide, defensin-mimetic compound, exhibits broad-spectrum anti-microbial and anti-SARS-CoV-2 activities.
Brilacidin at 0.5-1 µM has potent bactericidal activities against Gram-positive and Gram-negative bacteria, with minimal propensity for the development of resistance, causes membrane depolarization in Staphylococcus aureus (Gram-positive).
Brilacidin inhibits SARS-CoV-2 viral infection by blocking viral entry, inhibits pseudotyped SARS-CoV-2 viruses expressing spike proteins from the P.1 Brazil strain and the B.1.1.7 UK strain.
| M.Wt | 1082.75 | |
| Formula | C40H54Cl4F6N14O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N4,N6-bis(3-(5-((diaminomethylene)amino)pentanamido)-2-(((R)-pyrrolidin-3-yl)oxy)-5-(trifluoromethyl)phenyl)pyrimidine-4,6-dicarboxamide tetrahydrochloride |
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1. Mensa B, et al. Antimicrobial Agents and Chemotherapy 58.9 (2014): 5136–5145.
2. Chuan Xu, et al. EC Microbiol. 2022 Apr;18(4):1-12.
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