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Brilacidin tetrahydrochloride

Chemical Structure : Brilacidin tetrahydrochloride

CAS No.: 1224095-99-1

Brilacidin tetrahydrochloride (PMX-30063 tetrahydrochloride)

Catalog No.: PC-47040Not For Human Use, Lab Use Only.

Brilacidin (PMX-30063) is a synthetic, non-peptide, defensin-mimetic compound, exhibits broad-spectrum anti-microbial and anti-SARS-CoV-2 activities.

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Biological Activity

Brilacidin (PMX-30063) is a synthetic, non-peptide, defensin-mimetic compound, exhibits broad-spectrum anti-microbial and anti-SARS-CoV-2 activities.
Brilacidin at 0.5-1 µM has potent bactericidal activities against Gram-positive and Gram-negative bacteria, with minimal propensity for the development of resistance, causes membrane depolarization in Staphylococcus aureus (Gram-positive).
Brilacidin inhibits SARS-CoV-2 viral infection by blocking viral entry, inhibits pseudotyped SARS-CoV-2 viruses expressing spike proteins from the P.1 Brazil strain and the B.1.1.7 UK strain.

Physicochemical Properties

M.Wt 1082.75
Formula C40H54Cl4F6N14O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N4,N6-bis(3-(5-((diaminomethylene)amino)pentanamido)-2-(((R)-pyrrolidin-3-yl)oxy)-5-(trifluoromethyl)phenyl)pyrimidine-4,6-dicarboxamide tetrahydrochloride

References

1. Mensa B, et al. Antimicrobial Agents and Chemotherapy 58.9 (2014): 5136–5145.

2. Chuan Xu, et al. EC Microbiol. 2022 Apr;18(4):1-12.

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