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Chemical Structure : D66
Catalog No.: PC-47041Not For Human Use, Lab Use Only.
D66 is a specific small molecule that disrupts S. Typhimurium membrane voltage without cell lysis, prevents S. Typhimurium survival in macrophages (IC50=6.0 uM) and inhibits bacterial growth under conditions that compromise the cell envelope.
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D66 is a specific small molecule that disrupts S. Typhimurium membrane voltage without cell lysis, prevents S. Typhimurium survival in macrophages (IC50=6.0 uM) and inhibits bacterial growth under conditions that compromise the cell envelope.
D66 rapidly perturbs the bacterial cytoplasmic membrane with minor disruption of barrier function.
D66 disrupts voltage across the bacterial inner membrane at concentrations that do not permeabilize the inner membrane or lyse cells.
D66 does not permeabilize the mammalian cell membrane but does cause stress, as revealed by hyperpolarization of mitochondrial membranes.
| M.Wt | 378.297 | |
| Formula | C19H21Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jamie L Dombach, et al. PLoS Pathog. 2022 Jun 10;18(6):e1010606.
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