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TXA6101

Chemical Structure : TXA6101

CAS No.: 1459695-66-9

TXA6101 (TXA 6101)

Catalog No.: PC-49163Not For Human Use, Lab Use Only.

TXA6101 is an FtsZ-targeting compound with activity against MRSA isolates that express either G196S or G193D mutant FtsZ proteins, shows potent in vitro antibacterial activity against MRSA clinical isolate MPW020 with MIC of 0.125 ug/mL.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TXA6101 is an FtsZ-targeting compound with activity against MRSA isolates that express either G196S or G193D mutant FtsZ proteins, shows potent in vitro antibacterial activity against MRSA clinical isolate MPW020 with MIC of 0.125 ug/mL.
TXA6101 is active against both FtsZ mutant strains (G196S and G193D mutant FtsZ) with MIC of 1 ug/mL, but TXA707 is inactive.

Physicochemical Properties

M.Wt 477.185
Formula C18H10BrF5N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)methoxy)-2,6-difluorobenzamide

References

1. Fujita J, et al. ACS Chem Biol. 2017 Jul 21;12(7):1947-1955.

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