Cecropin B is an antimicrobial peptide with MICs (0.5 to 16 ug/ml) against Gram negative strain, also inhibit the expression of CYP3A29.
Cecropin B induces NF-κB activation playing a pivotal role in the suppression of CYP3A29 through disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA sequences.
Cecropin B activates pig liver cells by interacting with TLRs 2 and 4, which modulated NF-κB-mediated signaling pathways
