N-Acetyl-Calicheamicin |CAS:108212-76-6 Probechem Biochemicals

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Chemical Structure : N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin)

Catalog No.: PC-45713Not For Human Use, Lab Use Only.

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic; targets DNA and causes strand scission; a ADC payload in antibody drug conjugates development.

Physicochemical Properties

M.Wt	1410.385
Formula	C57H76IN3O22S4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyrano

References

1. Stasi R, et al. Cancer Treat Rev. 2008 Feb;34(1):49-60.

2. Naito K, et al. Leukemia. 2000 Aug;14(8):1436-43.

3. Hills RK, et al. Lancet Oncol. 2014 Aug;15(9):986-96.

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N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ;N-Acetyl-γ-calicheamicin)

Biological Activity

Physicochemical Properties

References

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