TU-514 | LpxC inhibitor | Probechem Biochemicals

Chemical Structure : TU-514

TU-514 (TU514)

Catalog No.: PC-24471Not For Human Use, Lab Use Only.

TU-514 is a substrate-analog inhibitor of zinc-dependent UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with Ki of 3.9 uM for E. coli LpxC and IC50 of 7.0 uM (A. aeolicus LpxC)

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Biological Activity

TU-514 is a substrate-analog inhibitor of zinc-dependent UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with Ki of 3.9 uM for E. coli LpxC and IC50 of 7.0 uM (A. aeolicus LpxC)

Physicochemical Properties

M.Wt	431.57
Formula	C22H41NO7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-Glucitol, 1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-, 3-tetradecanoate

References

1. Coggins BE, et al. Nat Struct Biol. 2003 Aug;10(8):645-51.

2. Jackman JE, et al. J Biol Chem. 2000 Apr 14;275(15):11002-9.

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TU-514 (TU514)

Biological Activity

Physicochemical Properties

References

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