Chemical Structure : HilD inhibitor C26
CAS No.:
930993-54-7
HilD inhibitor C26
Catalog No.: PC-24403Not For Human Use, Lab Use Only.
HilD inhibitor C26 is a specific small molecule inhibitor of S. Typhimurium transcriptional regulator HilD with IC50 of 16.9 uM and binds to HilD with an apparent Kd of 30.2 uM, inhibits the secretion of SipA with IC50 of 29.2 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HilD inhibitor C26 is a specific small molecule inhibitor of S. Typhimurium transcriptional regulator HilD with IC50 of 16.9 uM and binds to HilD with an apparent Kd of 30.2 uM, inhibits the secretion of SipA with IC50 of 29.2 uM.
C26 shows no effect on the thermal stability of HilC.
C26 inhibnits the DNA binding activity of HilD, whereas no effect on HilC activity.
C26 binds to the HilD homodimer to inhibit its binding to PhilA.
C26 blocked the expression of SipA, SctE, and SctP in whole cells, targets the regulatory pathway of Salmonella pathogenicity islands (SPIs) and reduces invasion into host cells.
C26 has an advantageous activity spectrum among S. Typhimurium clinical isolates, regardless of their source of isolation, sequence type, and antibiotic resistance profile.
Physicochemical Properties
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M.Wt
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397.29
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Formula
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C16H17BrN2O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(benzo[d][1,3]dioxol-5-ylmethyl)-2-(((5-bromothiophen-2-yl)methyl)(methyl)amino)acetamide
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References
1. Boudrioua A, et al. Sci Adv. 2025 Apr 11;11(15):eadr5235.
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