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Chemical Structure : AFN-1252
CAS No.: 620175-39-5
Catalog No.: PC-45087Not For Human Use, Lab Use Only.
AFN-1252 (API-1252, Debio 1452) is a potent inhibitor of bacterial enoyl-ACP reductase FabI.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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AFN-1252 (API-1252, Debio 1452) is a potent inhibitor of bacterial enoyl-ACP reductase FabI.
AFN-1252 demonstrates MICs of 0.015 and 0.008 ug/ml for S. aureus ATCC 29213 and S. aureus ATCC 33592 (MRSA), respectively.
AFN-1252 demonstrates a Staphylococcus-specific spectrum of activity.
| M.Wt | 375.4204 | |
| Formula | C22H21N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 5.8 mg/mL(Need ultrasonic) |
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| Chemical Name/SMILES |
2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-3-yl)-, (2E)- |
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1. Karlowsky JA, et al. Antimicrob Agents Chemother. 2007 Apr;51(4):1580-1.
2. Karlowsky JA, et al. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8.
3. Parsons JB, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15378-83.
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