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Vaborbactam

Chemical Structure : Vaborbactam

CAS No.: 1360457-46-0

Vaborbactam (RPX-7009, RPX7009)

Catalog No.: PC-45750Not For Human Use, Lab Use Only.

Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.

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Biological Activity

Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.
Vaborbactam (RPX-7009) restores meropenem activity for 72.7 to 98.1% of CPE isolates at ≤2 ug/ml.
Vaborbactam (RPX-7009)  showes no antibacterial activity alone (MICs, >64 ug/ml).

Physicochemical Properties

M.Wt 297.1351
Formula C12H16BNO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 10 mM

Chemical Name/SMILES

1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-[[2-(2-thienyl)acetyl]amino]-, (3R,6S)-

References

1. Castanheira M, et al. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5454-8.

2. Hecker SJ, et al. J Med Chem. 2015 May 14;58(9):3682-92.

3. Griffith DC, et al. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6326-32.

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