Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : G0507
CAS No.: 1223998-29-5
Catalog No.: PC-62513Not For Human Use, Lab Use Only.
G0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $698 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
G0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
G0507 treatment results in accumulation of fully processed Lpp, an outer membrane lipoprotein, in the inner membrane in E. coli cells.
G0507 still binds to LolCDE harboring a LolCQ258K mutation, which confers high-level resistance to G0507 in vivo, but no longer stimulates ATPase activity.
G0507 is a useful chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria.
| M.Wt | 353.396 | |
| Formula | C18H15N3O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(4-methoxyphenyl)-6-(5-methylthiophen-2-yl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dione |
|
1. Nickerson NN, et al. Antimicrob Agents Chemother. 2018 Jan 16. pii: AAC.02151-17.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
