Ganfeborole hydrochloride

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Chemical Structure : Ganfeborole hydrochloride

Catalog No.: PC-25241Not For Human Use, Lab Use Only.

Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
GSK3036656 displays no significant activity for human mitochondrial LeuRS and human cytoplasmic LeuRS (IC50>100 uM).
GSK3036656 shows potent antitubercular activity (Mtb H37Rv IC50=0.08 uM) in vitro.
GSK3036656 exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models.

Physicochemical Properties

M.Wt	293.94
Formula	C10H14BCl2NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

References

1. Li X,et al. J Med Chem. 2017 Oct 12;60(19):8011-8026.

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