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TBA-7371

Chemical Structure : TBA-7371

CAS No.: 1494675-86-3

TBA-7371 (TBA7371, AZ 7371)

Catalog No.: PC-49514Not For Human Use, Lab Use Only.

TBA-7371 (TBA7371, AZ 7371) is a potent, non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) with IC50 of 10 nM, an enzyme involved in mycobacterial cell wall biogenesis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TBA-7371 (TBA7371, AZ 7371) is a potent, non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) with IC50 of 10 nM, an enzyme involved in mycobacterial cell wall biogenesis.
TBA-7371 also inhibits PDE6 with an IC50 value of 4 uM.
TBA-7371 is active against M. tuberculosis with an MIC range of 0.78-3.12 µM and demonstrates efficacy in a rodent model of tuberculosis.

Physicochemical Properties

M.Wt 355.40
Formula C18H21N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-hydroxyethyl)-1-((6-methoxy-5-methylpyrimidin-4-yl)methyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

References

1. Robertson GT, et al. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0058321.

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