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JSF-2659

Chemical Structure : JSF-2659

CAS No.:

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JSF-2659 (JSF2659)

Catalog No.: PC-49257Not For Human Use, Lab Use Only.

JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 250 mg/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced colitis models.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JSF-2659 is the orally bioavailable, phosphate prodrug of JSF-2414, JSF-2659 (100 and 250 mg/kg, p.o.) is highly efficacious in reducing microbial burdens in animal models of Neisseria gonorrhoeae vaginal infection as well as VRSA and C. difficile-induced colitis models.

    Physicochemical Properties

    M.Wt 591.537
    Formula C25H31FN7O7P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (8-(6-fluoro-8-(methylamino)-2-((2-methylpyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-4-yl)-2-oxa-8-azaspiro[4.5]decan-3-yl)methyl dihydrogen phosphate hydrate

    References

    1. Steven Park, et al. Antimicrob Agents Chemother. 2022 Aug 16;e0041422.

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