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Chemical Structure : JMV-7061
Catalog No.: PC-49547Not For Human Use, Lab Use Only.
JMV7061 (JMV-7061) is a novel potent, selective bacterial metallo-β-lactamase (MBL) inhibitor, shows submicromolar activities against VIM-type enzymes and strong NDM-1 inhibition (Ki=10-30 nM).
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JMV7061 (JMV-7061) is a novel potent, selective bacterial metallo-β-lactamase (MBL) inhibitor, shows submicromolar activities against VIM-type enzymes and strong NDM-1 inhibition (Ki=10-30 nM).
JMV7061 inhibited both VIM-2 and NDM-1 at least partially by stripping the catalytic zinc ions.
JMV7061 also displayed a very potent synergistic activity with meropenem (16- to 1000-fold MIC reduction) against VIM-type- and NDM-1-producing ultraresistant clinical isolates, including Enterobacterales and Pseudomonas aeruginosa.
JMV7061 exhibited no or moderate toxicity toward HeLa cells, favorable absorption, distribution, metabolism, excretion (ADME) properties.
JMV7061 displayed no or modest inhibition of several mammalian metalloenzymes.
| M.Wt | 452.54 | |
| Formula | C21H24N8O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alice Legru, et al. J Med Chem. 2022 Dec 22;65(24):16392-16419.
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