TPN-0157345 | MmpL3 inhibitor | Probechem Biochemicals

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Chemical Structure : TPN-0157345

TPN-0157345 (TPN0157345)

Catalog No.: PC-24832Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TPN-0157345 is a small molecule inhibitor of Mycobacterium tuberculosis (M.tb) mycolic acid exporter MmpL3, targets cell wall biosynthesis, inhibits aerobically cultured M. tuberculosis H37Rv with IC90 of 3.3 uM.
TPN-0157345 has IC90 of 1.4 uM against intracellular M. tuberculosis H37Rv in THP-1 macrophages.

Physicochemical Properties

M.Wt	411.52
Formula	C21H25N5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-4-(1H-pyrazol-1-yl)-N-(1-(pyridin-4-ylmethyl)piperidin-4-yl)benzenesulfonamide

References

1. Allen R, et al. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0103724.

2. Maruti Naik, et al. ACS Med Chem Lett. 2014 Jul 11;5(9):1005-9.

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TPN-0157345 (TPN0157345)

Biological Activity

Physicochemical Properties

References

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