Chemical Structure : DRILS-1398
CAS No.:
2562305-87-5
DRILS-1398
(DRILS1398)
Catalog No.: PC-24816Not For Human Use, Lab Use Only.
DRILS-1398 is a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with IC50 of 3.0 uM, demonstrates efficacy against multi-drug resistant M.tb strains (MIC=4 ug/mL), inhibits M.tb amino acid biosynthetic pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DRILS-1398 is a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with IC50 of 3.0 uM, demonstrates efficacy against multi-drug resistant M.tb strains (MIC=4 ug/mL), inhibits M.tb amino acid biosynthetic pathway.
DRILS-1398 is capable of binding to the active site of the M.tb-CM and form a stable complex.
DRILS-1398 effectively inhibits intracellular M.tb in THP-1 macrophages.
Formulation of DRILS-1398 improves the pharmacokinetic and efficacy profile in the animal model.
Physicochemical Properties
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M.Wt
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436.34
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Formula
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C23H19Cl2N5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-(5-chloro-1H-indol-3-yl)-5-(4-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine
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References
1. Deepesh Biswas, et al. iScience. 2025 Apr 29;28(6):112537.
2. Patent WO 2020/240272 A1.
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