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Chemical Structure : Durlobactam sodium
CAS No.: 1467157-21-6
Catalog No.: PC-20706Not For Human Use, Lab Use Only.
Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.
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Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.
Durlobactam (ETX2514) potently inhibits clinically relevant class A, C and D β-lactamases and penicillin-binding proteins, resulting in intrinsic antibacterial activity against Enterobacteriaceae and restoration of β-lactam activity in a broad range of MDR Gram-negative pathogens.
Combination of sulbactam and ETX2514 shows potent antibacterial activity, in vivo efficacy against MDR A. baumannii infections.
Durlobactam (ETX2514) restores sulbactam activity against resistant Acinetobacter baumannii.
| M.Wt | 299.23 | |
| Formula | C8H10N3NaO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=S(ON1[C@]2([H])C=C(C)[C@@H](C(N)=O)[N@@](C2)C1=O)([O-])=O.[Na+] |
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1. Durand-Réville TF, et al. Nat Microbiol. 2017 Jun 30;2:17104.
2. McLeod SM, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01576-17.
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