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Chemical Structure : MAC13243
CAS No.: 1071638-38-4
Catalog No.: PC-20585Not For Human Use, Lab Use Only.
MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $798 | In stock | |
| 100 mg | $1780 | In stock | |
| 200 mg | Get quote | ||
| 200 mg | Get quote |
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MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
MAC13243 inhibits the function of the LolA protein and represents a new chemical probe of lipoprotein targeting in bacteria with promise as an antibacterial lead with Gram-negative selectivity.
MAC13243 exhibits promising activity against multidrug-resistant Pseudomonas aeruginosa.
| M.Wt | 442.40 | |
| Formula | C20H25Cl2N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
COC1=CC=C(CCN2CNC(SCC3=CC=C(Cl)C=C3)=NC2)C=C1OC.[H]Cl |
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1. Pathania R, et al. Nat Chem Biol. 2009 Nov;5(11):849-56.
2. Barker CA, et al. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2426-31.
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