| Cat. No. |
Product Name |
Information |
| PC-28034 |
N-butyryl-L-homoserine lactone
Quorum-sensing molecule
|
N-Butanoyl-L-homoserine lactone (C4-HSL) is a Pseudomonas aeruginosa quorum-sensing signal molecule, blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa, also is a cleavable ADC linker for synthesis of ADCs. |
| PC-28033 |
3OC12-HSL
Quorum-sensing molecule
|
3OC12-HSL is a P. aeruginosa quorum-sensing molecule, triggers quorum-sensing signal cascade, interacts with signal receptor-transcription factors LasR and QscR. |
| PC-27995 |
BVL3572S
Mtb HisC/AlaA inhibitor
|
BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis. |
| PC-27987 |
Obafluorin
Antibiotic, ThrRS inhibitor
|
Obafluorin is a beta-lactone antibiotic with activity against both Gram-positive and -negative pathogens, inhibits E. coli and P. fluorescens threonyl-tRNA synthetase (ThrRS, TRS) with IC50 of 35 nM and 4.3 nM respectively. |
| PC-27731 |
Afabicin
FabI inhibitor
|
Afabicin (Debio 1450, AFN-1720) is an antibiotic targets the staphylococcal enoyl-acyl carrier protein reductase (FabI) and exhibits selective potent antibacterial activity against staphylococcal species, including MRSA, |
| PC-27472 |
Luxafimloc
FimH inhibitor
|
Luxafimloc (GSK3882347) is a small molecule Escherichia coli fimbrial (FimH) adhesin inhibitor. |
| PC-27208 |
Kalamycin
METTL1 inhibitor, Antibiotic
|
Kalamycin (Kalafungin, U-19718, NSC137443) is an antibiotic, antimicrobial agent and β-lactamase inhibitor from marine Streptomyces, also is a potent inhibitor of METTL1 methyltransferase activity with IC50 of 8.9 uM, demonstrates potent antileukemia efficacy, also shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria. |
| PC-27159 |
UCP1172
DHFR inhibitor, Antifolate
|
UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG). |
| PC-26790 |
Forazemin
Peptide deformylase inhibitor
|
Forazemin (BB-83698) is a potent, orally active peptide deformylase (PDF) inhibitor, shows antibacterial potency for gram-positive pathogens with MIC50 of 0.25 ug/mL and 0.06 ug/mL for Streptococcus pneumoniae and Moraxella catarrhalis. |
| PC-26607 |
VNRX-14079
N. gonorrhoeae PBP2 inhibitor
|
VNRX-14079 is a specific Neisseria gonorrhoeae penicillin-binding protein (PBP2) inhibitor with IC50 of 1.7 uM for N. gonorrhoeae FA19 strain, exhibits potent antibacterial activity against multidrug-resistant N. gonorrhoeae through high-affinity binding to the PBP2. |
| PC-26097 |
CAI0019
E. faecium carbonic anhydrase inhibitor
|
CAI0019 (CAI-0019) is a potent, selective bacterial carbonic anhydrase (CA) inhibitor with Ki of 66.9 nM and 346 nM for E. faecium α-CA and E. faecium γ-CA. |
| PC-25764 |
JT71
MrkH inhibitor
|
JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation. |
