Cat. No. |
Product Name |
Information |
PC-20744 |
MAC13772
Biotin biosynthesis inhibitor
|
MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis. |
PC-20570 |
ML328
Bacterial AddAB complex inhibitor
|
ML328 is a first-in-class, dual inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 of 15.7 and 4.8 uM, respectively. |
PC-49514 |
TBA-7371
DprE1 inhibitor
|
TBA-7371 (TBA7371, AZ 7371) is a potent, non-covalent inhibitor of decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) with IC50 of 10 nM, an enzyme involved in mycobacterial cell wall biogenesis. |
PC-49256 |
JSF-2414
GyrB/ParE inhibitor
|
JSF-2414 (JSF2414) is a potent, small molecule GyrB/ParE dual binding inhibitor, simultaneously binds to ATP binding regions of DNA gyrase (GyrB) and topoisomerase (ParE) and displays potent in vitro activity against strains of MRSA, VRSA and VISA. |
PC-49186 |
SF235
Mip inhibitor
|
SF235 is a small-molecule inhibitor of macrophage infectivity potentiator (Mip) protein with IC50 and Ki 0.42 and 0.29 uM against B. pseudomallei Mip (BpMip) peptidyl-prolyl cis/trans isomerase (PPIase) activity, reduce B. pseudomallei virulence in vitro. |
PC-49180 |
BDM71339
EthR inhibitor
|
BDM71339 is the first small molecule inhibitor of mycobacterial transcriptional regulator EthR, boosts ten times the activity of ethionamide in TB-infected macrophages at low nanomolar concentrations (EC50=72 nM) in vitro. |
PC-49179 |
BVL-GSK098
VirS inhibitor
|
BVL-GSK098 (Alpibectir) is a small molecule able to inhibit Mycobacterium tuberculosis transcription regulator VirS, boosts bioactivation of ethionamide (ETH) and lower ETH MIC. |
PC-49166 |
TXA707
FtsZ inhibitor
|
TXA707 is the active metabolite of TXA709 and bacterial protein FtsZ inhibitor, maintains potent activity against S. aureus strains (e.g., MRSA, VRSA, DNSSA, and LNSSA) that are resistant to current SOC antibiotics. |
PC-49165 |
TXY541
FtsZ inhibitor
|
TXY541 is a 1-methylpiperidine-4-carboxamide prodrug of PC190723 and bacterial protein FtsZ inhibitor, TXY541 is efficacious in vivo in mouse models of systemic infection with both methicillin-sensitive and methicillin-resistant S. aureus. |
PC-49164 |
TXA709
FtsZ inhibitor
|
TXA709 is a prodrug of FtsZ-targeting benzamide compound (TXA707) with enhanced metabolic stability, demonstrates improved pharmacokinetic properties, and superior in vivo antistaphylococcal efficacy (both oral and intravenous) relative to previously identified prodrugs (TXY436 and TXY541) of PC190723. |
PC-49163 |
TXA6101
FtsZ inhibitor
|
TXA6101 is an FtsZ-targeting compound with activity against MRSA isolates that express either G196S or G193D mutant FtsZ proteins, shows potent in vitro antibacterial activity against MRSA clinical isolate MPW020 with MIC of 0.125 ug/mL. |
PC-49113 |
MD-124
Antibiotic adjuvant
|
MD-124 is a potent antibiotic adjuvant against Gram-negative bacteria, sensitizes various Gram-negative bacterial species and strains, including multidrug resistant pathogens, toward existing antibiotics. |