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UCP1172

Chemical Structure : UCP1172

CAS No.: 1922152-04-2

UCP1172

Catalog No.: PC-27159Not For Human Use, Lab Use Only.

UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG).

Physicochemical Properties

M.Wt 416.48
Formula C24H24N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

References

1. Reeve SM, et al. Cell Chem Biol. 2016;23(12):1458-1467.

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