JH-LPH-50

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Chemical Structure : JH-LPH-50

Catalog No.: PC-25652Not For Human Use, Lab Use Only.

JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	592.03
Formula	C24H29ClF3N5O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(3-(4-((4-(3-chloro-5-(trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)phenyl)ureido)-N-hydroxyhexanamide

References

1. Seung-Hwa Kwak, et al. ChemMedChem. 2023 Jun 1;18(11):e202300023.

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JH-LPH-50

Biological Activity

Physicochemical Properties

References

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