Chemical Structure : JT71
CAS No.:
380887-90-1
JT71
Catalog No.: PC-25764Not For Human Use, Lab Use Only.
JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation.
JT71 (50 uM) inhibited MrkH-mediated mrkA promoter activity by approximately 50%.
JT71 inhibits transcription from both the mrkA and mrkH promoters, does not impair bacterial viability.
JT71 (50 uM) reduces type 3 fimbriae production of K. pneumoniae.
JT71 inhibits biofilm formation in other type 3 fimbriated K. pneumoniae and Citrobacter koseri isolates.
JT71 inhibits biofilm formation independently of c-di-GMP abundance.
Physicochemical Properties
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M.Wt
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326.41
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Formula
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C18H18N2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)-2-methoxybenzamide
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References
1. Wilksch JJ, et al. NPJ Biofilms Microbiomes. 2025 Nov 20;11(1):212.
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