RyR2 inhibitor EL9

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Chemical Structure : RyR2 inhibitor EL9

Catalog No.: PC-20397Not For Human Use, Lab Use Only.

RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM.

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Biological Activity

RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM.
EL9 preferably targets the hyperactive mutant RyR2 channels.
EL9 prevented the induction of ventricular tachycardia observed in placebo-treated R176Q/+ mice, without affecting heart rate or cardiac contractility.

Physicochemical Properties

M.Wt	356.89
Formula	C18H29ClN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(diethylamino)ethyl 4-(butylamino)-5-chloro-2-methoxybenzoate

References

1. Na Li, et al. Int J Cardiol. 2017 Jan 15;227:668-673.

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