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Chemical Structure : RyR2 inhibitor EL9
Catalog No.: PC-20397Not For Human Use, Lab Use Only.
RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM.
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RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM.
EL9 preferably targets the hyperactive mutant RyR2 channels.
EL9 prevented the induction of ventricular tachycardia observed in placebo-treated R176Q/+ mice, without affecting heart rate or cardiac contractility.
| M.Wt | 356.89 | |
| Formula | C18H29ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Na Li, et al. Int J Cardiol. 2017 Jan 15;227:668-673.
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