| Cat. No. |
Product Name |
Information |
| PC-43138 |
Mirogabalin
Calcium channel α2δ ligand
|
Mirogabalin (DS-5565) is a potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively. |
| PC-43100 |
Dantrolene sodium hemiheptahydrate
Glutathione reductase inhibitor, RyR antagonist
|
Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells, inhibits Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
| PC-62867 |
(-)-CXL017
SERCA inhibitor
|
(-)-CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 13.5 uM. |
| PC-62866 |
CXL017
SERCA inhibitor
|
CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM. |
| PC-62070 |
Bay K-8644
L-type calcium channel activator
|
Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo. |
| PC-62009 |
Z-944
T-type calcium channel inhibitor
|
Z-944 (Ulixacaltamide) is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels. |
| PC-62008 |
ACT 709478
T-type calcium channel inhibitor
|
Apinocaltamide (ACT 709478) is a potent, selective, orally-bioavailable, brain penetrant T-type calcium channel blocker with IC50 of 6.4, 18, and 7.5 nM for Cav3.1, Cav3.2, and Cav3.3 channels respectively. |
| PC-61847 |
Pregabalin
VDCC inhibitor
|
Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs). |
| PC-61833 |
Imagabalin
VDCC inhibitor
|
Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2. |
| PC-61832 |
Atagabalin
VDCC inhibitor
|
Atagabalin (PD 0200390) is a novel ligand of the voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) for treatment for insomnia. |
| PC-61779 |
SERCA2a activator A
SERCA2a activator
|
SERCA2a activator A is a novel sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator that activates the Ca2+-dependent ATPase activity of cardiac SR vesicles but not that of skeletal muscle SR vesicles that lack of phospholamban (PLN). |
| PC-61012 |
DS16570511
MICU1 inhibitor
|
DS16570511 is a cell-permeable inhibitor of the mitochondrial calcium uniporter (MCU) that inhibits serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 uM. |
