| Cat. No. |
Product Name |
Information |
| PC-38082 |
Etripamil
Calcium channel blocker
|
Etripamil (MSP-2017) is a novel intranasal non-dihydropyridine calcium channel blocker that has begun phase III clinical trials for the treatment of paroxysmal supraventricular tachycardias.. |
| PC-35727 |
BTT-369
Cav2.2 inhibitor
|
BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays. |
| PC-35726 |
BTT-266
Cav2.2 inhibitor
|
BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM. |
| PC-35299 |
CDN1163
SERCA2 activator
|
CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes. |
| PC-35298 |
FPL64176
L-type Ca2+ channel activator
|
FPL64176 (ARC-64176) is a potent L-type Ca2+ channel activator with EC50 of 16 nM. |
| PC-63469 |
RU1968
CatSper inhibitor
|
RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3. |
| PC-63283 |
JTV-519 hemifumarate
SERCA inhibitor, RyR2 inhibitor
|
JTV-519 hemifumarate (K201) is a Ca2+-dependent blocker of SERCA and a ryanodine receptor 2 (RyR2) inhibitor. |
| PC-63282 |
JTV-519 hydrochloride
SERCA inhibitor, RyR2 inhibitor
|
JTV-519 hydrochloride (K201) is a Ca2+-dependent blocker of SERCA and a ryanodine receptor 2 (RyR2) inhibitor. |
| PC-63281 |
JTV-519
SERCA inhibitor, RyR2 inhibitor
|
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a ryanodine receptor 2 (RyR2) inhibitor. |
| PC-50011 |
Mirogabalin besylate
Calcium channel α2δ ligand
|
Mirogabalin besylate (DS-5565) is a novel potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively. |
| PC-43138 |
Mirogabalin
Calcium channel α2δ ligand
|
Mirogabalin (DS-5565) is a potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively. |
| PC-43100 |
Dantrolene sodium hemiheptahydrate
Glutathione reductase inhibitor, RyR antagonist
|
Dantrolene is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells, inhibits Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. |
