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BTT-266

Chemical Structure : BTT-266

CAS No.: 2413939-89-4

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BTT-266 (BTT266;BTT 266)

Catalog No.: PC-35726Not For Human Use, Lab Use Only.

BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM.
    BTT-266 decreases surface presentation of the CaV2.2α1 subunit, significantly reduces trafficking of CaV2.2 to the plasma membrane at 50 uM.
    BTT-266 does not affect CaV2.2 currents in either in HEK-CaV2.2 cells or rat dorsal root ganglion (DRG) neurons.

    Physicochemical Properties

    M.Wt 556.622
    Formula C34H28N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(5-(4-methoxyphenyl)-1'-phenyl-3'-(p-tolyl)-3,4-dihydro-1'H,2H-[3,4'-bipyrazole]-2-carbonyl)benzoic acid

    References

    1. Chen X, et al. Proc Natl Acad Sci U S A. 2018 Oct 24. pii: 201813157.

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