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Chemical Structure : BTT-266
Catalog No.: PC-35726Not For Human Use, Lab Use Only.
BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM.
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BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM.
BTT-266 decreases surface presentation of the CaV2.2α1 subunit, significantly reduces trafficking of CaV2.2 to the plasma membrane at 50 uM.
BTT-266 does not affect CaV2.2 currents in either in HEK-CaV2.2 cells or rat dorsal root ganglion (DRG) neurons.
| M.Wt | 556.622 | |
| Formula | C34H28N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen X, et al. Proc Natl Acad Sci U S A. 2018 Oct 24. pii: 201813157.
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