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BTT-369

Chemical Structure : BTT-369

CAS No.: 2413939-96-3

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BTT-369 (BTT 369;BTT 369)

Catalog No.: PC-35727Not For Human Use, Lab Use Only.

BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays.
    BTT-369 decreases trafficking of CaV2.2 channels to the plasma membrane and modulates the functions of the channel, suppresses pain responses in rodent neuropathic pain models.
    BTT-369 (BTT369) is a cell-permeable derivative of BTT-266.

    Physicochemical Properties

    M.Wt 580.652
    Formula C34H28N8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-(1H-tetrazol-5-yl)phenyl)(5-(4-methoxyphenyl)-1'-phenyl-3'-(p-tolyl)-3,4-dihydro-1'H,2H-[3,4'-bipyrazol]-2-yl)methanone

    References

    1. Chen X, et al. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10566-E10575.

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