Catalog No.: PC-50011Not For Human Use, Lab Use Only.
Mirogabalin besylate (DS-5565) is a novel potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively.
Mirogabalin besylate (DS-5565) is a potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively.
Mirogabalin besylate (DS-5565) exhibits a slower dissociation rate for the α2δ-1 subunit than the α2δ-2 subunit compared to pregabalin.
Mirogabalin besylate (DS-5565) shows more potent and longer lasting analgesic effects in experimental neuropathic pain models, partial sciatic nerve ligation rats and streptozotocin-induced diabetic rats.
Mirogabalin besylate (DS-5565) inhibits rota-rod performance and locomotor activity in rats.
Physicochemical Properties
M.Wt
367.46
Formula
C18H25NO5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)
References
1. Merante D, et al. Pain Med. 2017 Nov 1;18(11):2198-2207.
2. Vinik A, et al. Diabetes Care. 2014 Dec;37(12):3253-61.
3. Domon Y, et al. J Pharmacol Exp Ther. 2018 Mar 21. pii: jpet.117.247551.
