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Chemical Structure : Mirogabalin besylate
CAS No.: 1138245-21-2
Catalog No.: PC-50011Not For Human Use, Lab Use Only.
Mirogabalin besylate (DS-5565) is a novel potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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Mirogabalin besylate (DS-5565) is a potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively.
Mirogabalin besylate (DS-5565) exhibits a slower dissociation rate for the α2δ-1 subunit than the α2δ-2 subunit compared to pregabalin.
Mirogabalin besylate (DS-5565) shows more potent and longer lasting analgesic effects in experimental neuropathic pain models, partial sciatic nerve ligation rats and streptozotocin-induced diabetic rats.
Mirogabalin besylate (DS-5565) inhibits rota-rod performance and locomotor activity in rats.
| M.Wt | 367.46 | |
| Formula | C18H25NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1) |
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1. Merante D, et al. Pain Med. 2017 Nov 1;18(11):2198-2207.
2. Vinik A, et al. Diabetes Care. 2014 Dec;37(12):3253-61.
3. Domon Y, et al. J Pharmacol Exp Ther. 2018 Mar 21. pii: jpet.117.247551.
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