| Cat. No. |
Product Name |
Information |
| PC-23958 |
SERCA1 inhibitor CKP1
SERCA1 inhibitor
|
SERCA1 inhibitor CKP1 is a novel specific inhibitor of sarco/endoplasmic reticulum (ER) calcium ATPase 1 (SERCA1), induces severe ER stress-mediated apoptosis in metastatic PTC cells. |
| PC-23714 |
Ziconotide acetate
N-type calcium channel antagonist
|
Ziconotide acetate (SNX-111 acetate) is a potent and selective block of N-type calcium channels antagonist, reduces synaptic transmission. |
| PC-23713 |
ZC88
CaV2.2 inhibitor
|
ZC88 is a selective N-type calcium channel (CaV2.2) blocker, inhibits recombinant human N-type voltage-sensitive calcium channels (α1B/β1b/α2δ) transiently expressed in HEK-293 cells with IC50 of 0.45 uM. |
| PC-23712 |
C2230
CaV2.2 inhibitor
|
C2230 is a potent, specific CaV2.2 (N-type) calcium channel inhibitor/antagonist with IC50 of 1.3 uM (depolarizing Vh of -50 mV), preferably binds to the inactivated CaV2.2 channels. |
| PC-23650 |
ML218
T-type calcium channel inhibitor
|
ML218 (CID 45115620) is a selective, centrally active T-type Ca(2+) channel inhibitor with IC50 of 310 nM and 270 nM for Cav3.2 and Cav3.3 respectively in patch clamp electrophysiology. |
| PC-23295 |
Dicoumarol
VRAC inhibitor
|
Dicoumarol (Dicumarol) is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50 of 0.37 and 19.42 uM respectively, also is a potent VRAC inhibitor. |
| PC-23294 |
SN-89B
LRRC8 inhibitor
|
SN-89B is a potent LRRC8 channel inhibitorsuppresses agonist-induced platelet activation and aggregation (IC50=840 nM). |
| PC-23292 |
SN-406
LRRC8 inhibitor
|
SN-406 is a potent potent VRAC LRRC8 channels inhibitor with IC50 of 3.1 uM in HEK cells, suppress agonist-induced aggregation, ATP release, and calcium influx. |
| PC-23040 |
Nimodipine
L-type calcium channel inhibitor
|
Nimodipine (BAY-e 9736) is a highly selective inhibitor of L-type voltage-dependent calcium channels (VDCCs), prevents brain damage from reduced blood flow caused by aneurysm. |
| PC-22153 |
TTA-A2
T-type calcium channel inhibitor
|
TTA-A2 is a potent, selective, state-dependent T-type calcium channel antagonist with IC50 of 89 nM and 4100 nM in voltage clamp assays with -80-mV and -100-mV holding membrane potentials in HEK 293 cells heterologously expressing human CaV3.1, respectively. |
| PC-22078 |
MRS1845
SOCE channel inhibitor, Orai1 inhibitor
|
MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells. |
| PC-21849 |
TTA-Q6
T-type Ca2+ channel inhibitor
|
TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively. |
