Chemical Structure : SN-406
CAS No.:
SN-406
(SN406)
Catalog No.: PC-23292Not For Human Use, Lab Use Only.
SN-406 is a potent potent VRAC LRRC8 channels inhibitor with IC50 of 3.1 uM in HEK cells, suppress agonist-induced aggregation, ATP release, and calcium influx.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SN-406 is a potent potent VRAC LRRC8 channels inhibitor with IC50 of 3.1 uM in HEK cells, suppress agonist-induced aggregation, ATP release, and calcium influx.
SN-406 inhibit thrombin-stimulated platelet aggregation on LRRC8-mediated ATP currents in patch-clamp studies. reduces both thrombin- and PAR4-AP- stimulated Ca2+ flux.
SN-406 significantly suppresses human platelet aggregation in response to PAR1+PAR4 stimulation and impairs agonist-induced Ca2+ signaling in mouse platelets.
SN-406 exhibits a clear dose-response relationship in PAR4-AP-induced mouse platelet aggregation with IC50 of 1.1 uM.
LRRC8A (leucine-rich repeat-containing protein 8A, also known as SWELL1) is the essential subunit of the heterohexameric LRRC8 volume-regulated anion channel (VRAC), which contain at least one LRRC8A subunit in combination with, B, C, D and/or E subunits.
Physicochemical Properties
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M.Wt
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469.44
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Formula
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C25H34Cl2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-((6,7-dichloro-2-cyclopentyl-1-oxo-2-pentyl-2,3-dihydro-1H-inden-5-yl)oxy)hexanoic acid
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References
1. Gunasekar SK, et al. Nat Commun. 2022 Feb 10;13(1):784.
2. Lauren J Lahey, et al. Mol Cell. 2020 Nov 19;80(4):578-591.e5.
3. Tranter JD, et al. bioRxiv [Preprint]. 2024 Sep 26:2024.09.26.615233.
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