| Cat. No. |
Product Name |
Information |
| PC-23292 |
SN-406
LRRC8 inhibitor
|
SN-406 is a potent potent VRAC LRRC8 channels inhibitor with IC50 of 3.1 uM in HEK cells, suppress agonist-induced aggregation, ATP release, and calcium influx. |
| PC-23040 |
Nimodipine
L-type calcium channel inhibitor
|
Nimodipine (BAY-e 9736) is a highly selective inhibitor of L-type voltage-dependent calcium channels (VDCCs), prevents brain damage from reduced blood flow caused by aneurysm. |
| PC-22420 |
M201-A
RyR2 inhibitor
|
M201-A is a potent, selective ryanodine receptor 2 (RyR2) inhibitor, significantly reduces the diastolic Ca2+ in isolated rat ventricular cardiomyocytes, exhibits positive lusi-inotropic effects on rat heart. |
| PC-22153 |
TTA-A2
T-type calcium channel inhibitor
|
TTA-A2 is a potent, selective, state-dependent T-type calcium channel antagonist with IC50 of 89 nM and 4100 nM in voltage clamp assays with -80-mV and -100-mV holding membrane potentials in HEK 293 cells heterologously expressing human CaV3.1, respectively. |
| PC-22078 |
MRS1845
SOCE channel inhibitor, Orai1 inhibitor
|
MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells. |
| PC-21849 |
TTA-Q6
T-type Ca2+ channel inhibitor
|
TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively. |
| PC-21384 |
CBD3063
CaV2.2 inhibitor
|
CBD3063 is a selective, first-in-class inhibitor of Cav2.2-CRMP2 (ollapsin response mediator protein 2) interaction, suppresses surface trafficking of Cav2.2, and N-type (Cav2.2) calcium currents. |
| PC-21371 |
S107
RyR2 stabilizer
|
S107 (RyR2 stabilizer) is a specific stabilizing cmpound of Ca2+ release channel ryanodine receptor 2 (RyR2), enhances calstabin2 binding and inhibits Ca2+ leak from mutant RyR2 channels. |
| PC-21312 |
TMDJ-035
RyR2 inhibitor
|
TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3. |
| PC-20690 |
Ebselen
VDCC blocker
|
Ebselen (CCG-39161, PI-1005) is a potent voltage-dependent calcium channel (VDCC) blocker, also potently inhibits SARS CoV-2 Mpro with IC50 of 0.67 μM. |
| PC-20657 |
Extracellular vesicle enhancer 634
Extracellular vesicle enhancer
|
Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE). |
| PC-36028 |
SAK3
|
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro. |
