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Cat. No. Product Name Information
PC-23293

SN-407

LRRC8 inhibitor

SN-407 is a potent VRAC inhibitor with IC50 of 1.6 uM in HEK cells, targets LRRC8 complex and blocks agonist-induced aggregation, ATP release, and calcium influx in platelets.
PC-23292

SN-406

LRRC8 inhibitor

SN-406 is a potent potent VRAC LRRC8 channels inhibitor with IC50 of 3.1 uM in HEK cells, suppress agonist-induced aggregation, ATP release, and calcium influx.
PC-23040

Nimodipine

L-type calcium channel inhibitor

Nimodipine (BAY-e 9736) is a highly selective inhibitor of L-type voltage-dependent calcium channels (VDCCs), prevents brain damage from reduced blood flow caused by aneurysm.
PC-22420

M201-A

RyR2 inhibitor

M201-A is a potent, selective ryanodine receptor 2 (RyR2) inhibitor, significantly reduces the diastolic Ca2+ in isolated rat ventricular cardiomyocytes, exhibits positive lusi-inotropic effects on rat heart.
PC-22153

TTA-A2

T-type calcium channel inhibitor

TTA-A2 is a potent, selective, state-dependent T-type calcium channel antagonist with IC50 of 89 nM and 4100 nM in voltage clamp assays with -80-mV and -100-mV holding membrane potentials in HEK 293 cells heterologously expressing human CaV3.1, respectively.
PC-22078

MRS1845

SOCE channel inhibitor, Orai1 inhibitor

MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells.
PC-21849

TTA-Q6

T-type Ca2+ channel inhibitor

TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively.
PC-21384

CBD3063

CaV2.2 inhibitor

CBD3063 is a selective, first-in-class inhibitor of Cav2.2-CRMP2 (ollapsin response mediator protein 2) interaction, suppresses surface trafficking of Cav2.2, and N-type (Cav2.2) calcium currents.
PC-21371

S107

RyR2 stabilizer

S107 (RyR2 stabilizer) is a specific stabilizing cmpound of Ca2+ release channel ryanodine receptor 2 (RyR2), enhances calstabin2 binding and inhibits Ca2+ leak from mutant RyR2 channels.
PC-21312

TMDJ-035

RyR2 inhibitor

TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3.
PC-20690

Ebselen

VDCC blocker

Ebselen (CCG-39161, PI-1005) is a potent voltage-dependent calcium channel (VDCC) blocker, also potently inhibits SARS CoV-2 Mpro with IC50 of 0.67 μM.
PC-20657

Extracellular vesicle enhancer 634

Extracellular vesicle enhancer

Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE).

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