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A-1048400

Chemical Structure : A-1048400

CAS No.: 1219624-62-0

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A-1048400 (A1048400)

Catalog No.: PC-60006Not For Human Use, Lab Use Only.

A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
    A-1048400 shows no significant activity against L-type Ca2+ channels (IC50=28 uM).
    A-1048400 reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function.
    A-1048400 blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo.

    Physicochemical Properties

    M.Wt 543.711
    Formula C36H37N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one

    References

    1. Scott VE, et al. Biochem Pharmacol. 2012 Feb 1;83(3):406-18.

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