Catalog No.: PC-45854Not For Human Use, Lab Use Only.
NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
NNC 55-0396 has no detectable effect on high-voltage-activated channels in INS-1 cells.
NNC 55-0396 inhibits MCF-7 (ERalpha+) cellular proliferation, inhibits tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1α stability.
NNC 55-0396 significantly suppresses glioblastoma tumor growth in a xenograft model.
NNC 55-0396 is a small molecule inhibitor of the PEX3-PEX19 interaction, effectively disrupts PEX3-PEX19 interaction at 4 μM.
NNC 55-0396 shows anti-tumoral effect, which is dependent on peroxisomal functions, but not on T-type calcium channels (TTCCs).
NNC 55-0396 shows anti-tumor response with MAPK-targeted therapy in melanoma.
