Chemical Structure : ZC88
CAS No.:
919510-41-1
ZC88
Catalog No.: PC-23713Not For Human Use, Lab Use Only.
ZC88 is a selective N-type calcium channel (CaV2.2) blocker, inhibits recombinant human N-type voltage-sensitive calcium channels (α1B/β1b/α2δ) transiently expressed in HEK-293 cells with IC50 of 0.45 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ZC88 is a selective N-type calcium channel (CaV2.2) blocker, inhibits recombinant human N-type voltage-sensitive calcium channels (α1B/β1b/α2δ) transiently expressed in HEK-293 cells with IC50 of 0.45 uM.
ZC88 (100 uM) has no effect on the L-type (α1C/β1b/α2δ), R-type (α1E/β1b/α2δ) and P/Q-type (α1A/β1b/α2δ) voltage-sensitive calcium channel currents transiently expressed in Xenopus oocytes.
ZC88 (10–80 mg/kg) administered by oral route showed significant antinociceptive effects in a dose-dependent manner.
ZC88 (20–80 mg/kg) dose-dependently potentiated morphine analgesia and attenuated morphine analgesic tolerance in hot-plate tests.
ZC88 also prevented chronic exposure to morphine-induced physical dependence and withdrawal, but not morphine-induced psychological dependence in conditioned place preference model.
Physicochemical Properties
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M.Wt
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550.36
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Formula
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C24H35BrCl2N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[1-(2,3-dimethoxyphenyl)-4-methyl-3-pentene-1-yl]-1-(5-bromo-furfuryl)- 1-piperidyl-4-amine dihydrochloride
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References
1. Meng G, et al. Eur J Pharmacol. 2008 May 31;586(1-3):130-8.
2. Hu L.Y. et al. Bioorg. Med. Chem., 8 (2000), pp. 1203-1212
3. Zhang S, et al. Brain Res. 2015 Apr 24;1605:12-21.
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