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NS-638

Chemical Structure : NS-638

CAS No.: 150493-34-8

NS-638 (NS638, NS 638)

Catalog No.: PC-42385Not For Human Use, Lab Use Only.

NS-638 is a nonpeptide calcium channel blocker that dose dependently inhibits AMPA-stimulated [3H]GABA-release from cultured cortical neurons with IC50 of 4.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NS-638 is a nonpeptide calcium channel blocker that dose dependently inhibits AMPA-stimulated [3H]GABA-release from cultured cortical neurons with IC50 of 4.3 uM.
NS-638 blocks K(+)-stimulated intracellular Ca(2+)-elevation in cultured cerebellar granule cells with IC50 of 3.4 uM.
NS-638 reversibly blocks N- and L-type Ca(2+)-channels in cultured chick dorsal root ganglion cells (1-30 uM).
NS-638 exhibits anti-ischemic properties in vivo.

Physicochemical Properties

M.Wt 325.7161496
Formula C15H11ClF3N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

1H-Benzimidazol-2-amine, 1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-

References

1. Møller A, et al. Neurol Res. 1995 Oct;17(5):353-60.

2. Olesen SP, et al. Acta Neurol Scand. 1997 Apr;95(4):219-24.

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