| Cat. No. |
Product Name |
Information |
| PC-38452 |
VK-II-36
RyR2 inhibitor
|
VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2). |
| PC-38432 |
Zegocractin
Orai1 channel inhibitor
|
Zegocractin (CM4620) is a selective small molecule CRAC (Orai1) channel inhibitor, inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of 120 nM and 900 nM, respectively. |
| PC-72941 |
DCPIB
VRAC inhibitor
|
DCPIB (SN-401) is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), inhibits TRESK, TASK1 and TASK3 with IC50 of 0.14, 0.95, and 50.72 uM respectively. |
| PC-72884 |
USP5-Cav3.2 inhibitor II-1
USP5-Cav3.2 inhibitor
|
USP5-Cav3.2 inhibitor II-1 is a small molecule inhibitor of USP5-Cav3.2 interaction, without affecting the enzymatic activity of USP5. |
| PC-72456 |
RyR1 inhibitor compound 1
RyR1 inhibitor
|
RyR1 inhibitor compound 1 is a potent, RyR1-selective inhibitor, inhibits the RyR1 channel with IC50 of 12 nM in HEK293 cell-based assay. |
| PC-38082 |
Etripamil
Calcium channel blocker
|
Etripamil (MSP-2017) is a novel intranasal non-dihydropyridine calcium channel blocker that has begun phase III clinical trials for the treatment of paroxysmal supraventricular tachycardias.. |
| PC-35727 |
BTT-369
Cav2.2 inhibitor
|
BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays. |
| PC-35726 |
BTT-266
Cav2.2 inhibitor
|
BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM. |
| PC-35299 |
CDN1163
SERCA2 activator
|
CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes. |
| PC-63469 |
RU1968
CatSper inhibitor
|
RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3. |
| PC-63281 |
JTV-519
SERCA inhibitor
|
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs). |
| PC-50011 |
Mirogabalin besylate
Calcium channel α2δ ligand
|
Mirogabalin besylate (DS-5565) is a novel potent, selective ligand of the α2δ subunit of voltage-gated calcium channels with Kd of 13.5/22.7/27.0/47.6 nM for huamn α2δ-1, human α2δ-2, rat α2δ-1 and rat α2δ-2 subunits, respectively. |
