| Cat. No. |
Product Name |
Information |
| PC-49242 |
TPC2-A1-P
TPC2 agonist
|
TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
| PC-49241 |
TPC2-A1-N
TPC2 agonist
|
TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
| PC-47015 |
2E151
Calcium channel activator
|
2E151 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-47014 |
2D216
Calcium channel activator
|
2D216 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-38654 |
CRAC inhibitor 36
CRAC channel inhibitor
|
CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition). |
| PC-38485 |
VK-II-86
RyR2 inhibitor
|
VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2). |
| PC-38452 |
VK-II-36
RyR2 inhibitor
|
VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2). |
| PC-38432 |
Zegocractin
Orai1 channel inhibitor
|
Zegocractin (CM4620) is a selective small molecule CRAC (Orai1) channel inhibitor, inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of 120 nM and 900 nM, respectively. |
| PC-72941 |
DCPIB
VRAC inhibitor
|
DCPIB (SN-401) is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), inhibits TRESK, TASK1 and TASK3 with IC50 of 0.14, 0.95, and 50.72 uM respectively. |
| PC-72884 |
USP5-Cav3.2 inhibitor II-1
USP5-Cav3.2 inhibitor
|
USP5-Cav3.2 inhibitor II-1 is a small molecule inhibitor of USP5-Cav3.2 interaction, without affecting the enzymatic activity of USP5. |
| PC-72547 |
SG-094
TPC2 inhibitor
|
SG-094 (SG094) is a specific cytostatic two-pore channel 2 (TPC2) inhibitor with IC50 of 8.3 uM (TPC2 activator TPC2-A1-P inhibition), shows antiproliferative effect on RIL175 cells with IC50 of 3.7 uM. |
| PC-72456 |
RyR1 inhibitor compound 1
RyR1 inhibitor
|
RyR1 inhibitor compound 1 is a potent, RyR1-selective inhibitor, inhibits the RyR1 channel with IC50 of 12 nM in HEK293 cell-based assay. |
