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TPC2-A1-N

Chemical Structure : TPC2-A1-N

CAS No.: 136186-07-7

TPC2-A1-N

Catalog No.: PC-49241Not For Human Use, Lab Use Only.

TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.

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    Biological Activity

    TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.
    TPC2-A1-N evokes Na+ currents in isolated endo-lysosomes with EC50 of 0.6 uM in endo-lysosomal patch-clamp experiments.
    TPC2-A1-P but not TPC2-A1-N promoted lysosomal exocytosis.
    TPC2-A1-N increases the pH in the lysosomal lumen in a TPC2-dependent manner, TPC2-A1-P has no significant effect on lysosomal pH.

    Physicochemical Properties

    M.Wt 401.166
    Formula C17H9Cl2F3N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide

    References

    1. Susanne Gerndt, et al. Elife. 2020 Mar 16;9:e54712.

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