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CRAC inhibitor 36

Chemical Structure : CRAC inhibitor 36

CAS No.: 1373938-48-7

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CRAC inhibitor 36

Catalog No.: PC-38654Not For Human Use, Lab Use Only.

CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).
    CRAC inhibitor 36 showed decent potency and selectivity and a remarkable pharmacokinetic profile, good target engagement as measured by levels of IL-2 and TNF-α.

    Physicochemical Properties

    M.Wt 421.404
    Formula C23H17F2N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,6-difluoro-N-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide

    References

    1. Khedkar NR, et al. J Med Chem. 2021 Dec 9;64(23):17004-17030.

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