CRAC inhibitor 36

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Chemical Structure : CRAC inhibitor 36

Catalog No.: PC-38654Not For Human Use, Lab Use Only.

CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).
CRAC inhibitor 36 showed decent potency and selectivity and a remarkable pharmacokinetic profile, good target engagement as measured by levels of IL-2 and TNF-α.

Physicochemical Properties

M.Wt	421.404
Formula	C23H17F2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-difluoro-N-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide

References

1. Khedkar NR, et al. J Med Chem. 2021 Dec 9;64(23):17004-17030.

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